Adrian Sanz-Moreno

1 month ago | science.org | Sanghun Lee |Adrian Sanz-Moreno |Karishma D'Sa |Ashley Rowe

INTRODUCTIONNeurodegenerative disorders represent major sources of human suffering, yet the factors influencing disease severity remain poorly understood. Sex has been implicated as one such factor in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and age-related macular degeneration (1–5).

Dec 4, 2024 | nature.com | Tim Hasenbein |Sarah Hoelzl |Zachary Smith |Chiara Gerhardinger |Oana Amarie |Lore Becker | +9 more

AbstractThe lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest conserved chromatin structures. Here, we characterize the epigenetic profile of these loci, revealing them as the most female-specific accessible regions genome-wide.