Ang Li

Dec 4, 2024 | biorxiv.org | Ang Li |Li Dong |Xuejun Li |Jianxun Yi

AbstractDifferent muscles exhibit varied susceptibility to degeneration in Amyotrophic Lateral Sclerosis (ALS), a fatal neuromuscular disorder. Extraocular muscles (EOMs) are particularly resistant to ALS progression and exploring the underlying molecular nature may deliver great therapeutic value. Reactive aldehyde 4-hydroxynonenal (HNE) is implicated in ALS pathogenesis and ALDH3A1 is an inactivation-resistant intracellular detoxifier of 4-HNE protecting eyes against UV-induced oxidative stress.

Jul 19, 2024 | bmccancer.biomedcentral.com | Ang Li |Hui Gao |Hongjiao Wu |Yuning Xie |Zhenxian Jia |Zhenbang Yang | +2 more

This study includes 410 colon cancer patients and 410 healthy controls. Cases were collected from Jan 2008 to Dec 2016 at Tangshan Renmin Hospital and Gongren Hospital of North China University of Science and Technology (NCST) in China with histopathological confirmation. Cancer-free healthy controls were collected from Tangshan area. All participants were genetically unrelated Han Chinese. Informed consent was provided by every individual.

Jul 3, 2024 | mdpi.com | Wei Qi |Ang Li |Honghai Zhang

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Jun 12, 2024 | mdpi.com | Bin Chen |Jun Yang |Ang Li |Min Zhang

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

Apr 25, 2024 | elifesciences.org | Ang Li |Jianxun Yi |Xuejun Li |Li Dong

eLife assessment The manuscript by Jingsong Zhou and colleagues uncovers why the extraocular muscles (EOMs) are preserved while other muscles undergo degenerative changes in amyotrophic lateral sclerosis (ALS). In this work, the authors have used a mouse model of familial ALS that carries a G93A mutation in the Sod1 gene to demonstrate that NaBu treatment partially restores the integrity of NMJ in the limb and diaphragm muscles of G93A mice.