Valeria Visconte

Jan 4, 2025 | nature.com | Valeria Visconte

To the Editor:CBL proteins are a family of RING finger E3 ubiquitin ligases that regulate proliferative signals via ubiquitination and degradation of tyrosine-phosphorylated signaling proteins, such as KIT, CSF-1, FLT3 and PDGF [1]. We previously described c-CBL RING finger mutations in myeloid neoplasia (MN), chiefly myelodysplastic/myeloproliferative (MDS/MPN) syndromes such as chronic myelomonocytic leukemia [2, 3] and juvenile myelomonocytic leukemia [4].

Nov 21, 2024 | nature.com | Carlos Bravo-Pérez |Yasuo Kubota |Simona Pagliuca |Danai Dima |Hetty Carraway |Valeria Visconte

AbstractPast studies described occasional patients with myeloid neoplasms (MN) and coexistent large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance (TCUS), which may represent expansion of myeloid clonal hematopoiesis (CH) as triggers or targets of clonal cytotoxic T cell reactions. We retrospectively analyzed 349 LGLL/TCUS patients, 672 MN patients, and 1443 CH individuals to establish the incidence, genetic landscape, and clinical phenotypes of CH in LGLL.

Nov 14, 2024 | onlinelibrary.wiley.com | Carmelo Gurnari |Valeria Visconte

In their paper, Li et al.1 embarked in the understanding of the determinants of evolution to myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) in patients with aplastic anaemia (AA) and paroxysmal nocturnal haemoglobinuria. The authors specifically focused on patients undergoing allogeneic haematopoietic cell transplant (allo-HCT) to study outcomes and differences with patients with AA receiving transplant upfront before progressing to MDS/secondary AML (sAML).

Jul 29, 2024 | nature.com | Fauzia Ullah |Danai Dima |Hetty Carraway |Chao-Yie Yang |Carmelo Gurnari |Valeria Visconte | +1 more

TO THE EDITOR:FMS-like receptor tyrosine kinase 3 (FLT3) expression is almost exclusively found in the myeloid compartment [1]. The FLT3 protein consists of an extracellular region containing the ligand-binding site, a transmembrane domain, a cytoplasmic juxtamembrane domain, and a tyrosine kinase domain (TKD).

Jul 17, 2024 | nature.com | Tariq Kewan |Olisaemeka Ogbue |Sudipto Mukherjee |Anjali Advani |James Cook |Hetty Carraway | +2 more

TO THE EDITOR:Extramedullary deposits of acute myeloid leukemia (eAML), constitute an unusual presentation or complication of AML, which can occur in isolation (isolated eAML) or in the context of a fully-blown leukemic process (synchronous eAML) either at diagnosis or relapse [1,2,3].