Chenxiao Wang

Oct 14, 2024 | mdpi.com | Yuchen Wei |Bin Wang |Ke Wu |Chenxiao Wang

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Sep 16, 2024 | nature.com | Chenxiao Wang |Calder Ellsworth |Nicholas J. Maness |Robert Blair |Jay Kolls |Janet E. Mccombs

AbstractToll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficiency mice, single-cell RNA analysis together with bone marrow transplantation approaches. We demonstrate that at the early phase of infection, SARS-CoV-2 causes the upregulation of Tlr7, Irf7, and IFN pathways in the lungs of the infected mice.

Dec 12, 2023 | nature.com | Chenxiao Wang |Zhe Zhang |Xiao-Ming Yin |Nicholas J. Maness |Robert Blair |Jay Kolls | +1 more

AbstractSARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation and collagen deposition at 21 and 45 days post infection (DPI).