Janet E. Mccombs

Sep 16, 2024 | nature.com | Chenxiao Wang |Calder Ellsworth |Nicholas J. Maness |Robert Blair |Jay Kolls |Janet E. Mccombs

AbstractToll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficiency mice, single-cell RNA analysis together with bone marrow transplantation approaches. We demonstrate that at the early phase of infection, SARS-CoV-2 causes the upregulation of Tlr7, Irf7, and IFN pathways in the lungs of the infected mice.