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Sep 16, 2024 | 
nature.com | Chenxiao Wang |Calder Ellsworth |Nicholas J. Maness |Robert Blair |Jay Kolls |Janet E. Mccombs
AbstractToll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficiency mice, single-cell RNA analysis together with bone marrow transplantation approaches. We demonstrate that at the early phase of infection, SARS-CoV-2 causes the upregulation of Tlr7, Irf7, and IFN pathways in the lungs of the infected mice.
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Aug 20, 2024 | 
nature.com | Clovis S. Palmer |Chrysostomos Perdios |Mohamed Abdel-Mohsen |Nicholas J. Maness |Nadia Golden |Kelsey Williams | +4 more
AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys.
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Feb 15, 2024 | 
williamsonherald.com | Robert Blair
Each year we are excited for the challenge of exploring and presenting a theme that will have the readers and advertisers excited to be part of this annual special edition.
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Feb 14, 2024 | 
williamsonherald.com | Robert Blair
Each year we are excited for the challenge of exploring and presenting a theme that will have the readers and advertisers excited to be part of this annual special edition.
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Feb 6, 2024 | 
nature.com | John Tully |Steve Williams |Robert Blair |Declan Murphy
AbstractMen with antisocial personality disorder (ASPD) with or without psychopathy (+/−P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies.
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Dec 12, 2023 | 
nature.com | Chenxiao Wang |Zhe Zhang |Xiao-Ming Yin |Nicholas J. Maness |Robert Blair |Jay Kolls | +1 more
AbstractSARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation and collagen deposition at 21 and 45 days post infection (DPI).
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Sep 14, 2023 | 
williamsonherald.com | Robert Blair
Nestled in a shopping area located on Columbia Avenue in Franklin is a hidden treasure. When you enter the space, you immediately feel a sense of warmth and belonging. The atmosphere is inviting and relaxing, which allows clients to engage each other as friends. This is what Soul Society Beauty and Boutique owner and operator Kayla Dockins wants her clients to feel. “When they enter they become friends, not only of mine but of each other,” she said.
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May 25, 2023 | 
williamsonherald.com | Robert Blair |Lily Hardy Hammond
Paying it forward is like giving a smile — it’s easy to do. The gesture often presents itself in various opportunities and situations. I encountered one of those opportunities recently, and it was truly a blessing. I’ll tell more about the situation in a bit, but first a little history and perspective.
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May 11, 2023 | 
nature.com | Robert Blair |Michael Weintraub
AbstractGovernments in low- and middle-income countries routinely deploy their armed forces for domestic policing operations. Advocates of these policies claim they reduce crime, while detractors argue they undermine human rights. Here we experimentally evaluate a military policing intervention in Cali, Colombia. The intervention involved recurring, intensive military patrols targeting crime hot spots, randomly assigned at the city block level.
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May 4, 2023 | 
jpet.aspetjournals.org | Robert Blair |Elisa Hawkins |Lauren Pinchbeck |Robert DeLorenzo
AbstractOrganophosphate (OP) compounds are highly toxic and include pesticides and chemical warfare nerve agents. OP exposure inhibits the acetylcholinesterase enzyme, causing cholinergic overstimulation that can evolve into status epilepticus (SE) and produce lethality. Furthermore, OP-induced SE survival is associated with mood and memory dysfunction and spontaneous recurrent seizures (SRS).
