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1 month ago | 
nature.com | Pravesh Parekh |Sara Stinson |Maria Koromina |Jaroslav Rokicki |Ida E Sønderby |Nadine Staples Parker | +11 more
AbstractMetabolites in plasma form biosignatures of a range of common complex human diseases. Discovering variants with pleiotropic effects across metabolites can reveal underlying biological mechanisms. We therefore performed uni- and multivariate genome-wide association studies (GWAS) on 249 circulating metabolic markers across 328,006 UK Biobank and Estonian Biobank participants.
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Sep 20, 2024 | 
onlinelibrary.wiley.com | Markos Tesfaye |Piotr Jaholkowski |Alexey Shadrin |Guy Hindley
Anxiety, characterized by excessive fear, anxiousness, or avoidance behaviors, is a core feature of anxiety disorders.1 Anxiety disorders are among the leading causes of global disease burden.2 The extensive overlap and comorbidity among anxiety disorders3 have led to a growing view of them as a continuum rather than discrete categories.4, 5 Epidemiological data show frequent comorbidity between anxiety disorders and other psychiatric disorders,3 including depressive disorders,6 bipolar...
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Jun 3, 2024 | 
nature.com | Oleksandr Frei |Guy Hindley |Espen Hagen |Nadine Staples Parker |Olav B. Smeland |Christiaan de Leeuw | +2 more
AbstractWhile genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging.
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Apr 29, 2024 | 01000-x/abstract?rss=yes&sz=64)
biologicalpsychiatryjournal.com | Nadine Staples Parker |Piotr Jaholkowski |Guy Hindley |Elise Koch
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Apr 5, 2024 | 
digitalcommons.library.tmc.edu | Guy Hindley |Alexey Shadrin |Nadine Staples Parker |Weiqiu Cheng
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Feb 27, 2024 | 
medrxiv.org | Alexey Shadrin |Guy Hindley |Espen Hagen |Nadine Staples Parker
Srdjan Djurovic has received speaker's Honoria from Lundbeck. Anders M. Dale is a Founder of and holds equity in CorTechs Labs, Inc, and serves on its Scientific Advisory Board. He is also a member of the Scientific Advisory Board of Human Longevity, Inc. (HLI), and the Mohn Medical Imaging and Visualization Centre in Bergen, Norway. He receives funding through a research agreement with General Electric Healthcare (GEHC).
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Feb 20, 2024 | 
medrxiv.org | Nadine Staples Parker |Weiqiu Cheng |Guy Hindley |Kevin O'Connell
A.M.D. is a Founder of and holds equity in CorTechs Labs, Inc, and serves on its Scientific Advisory Board. A.M.D. is a member of the Scientific Advisory Board of Human Longevity, Inc. (HLI), and the Mohn Medical Imaging and Visualization Centre in Bergen, Norway. A.M.D. receives funding through a research agreement with General Electric Healthcare (GEHC).
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Sep 27, 2023 | 
ajp.psychiatryonline.org | Linn Rødevand |Zillur Rahman |Guy Hindley |Olav B. Smeland
Schizophrenia is associated with a two- to threefold greater risk of cardiovascular disease (CVD) compared with risk in the general population, contributing to a 10- to 20-year reduced life expectancy (1, 2). Despite increasing awareness of this comorbidity over recent decades, the level of CVD risk does not appear to have decreased for individuals with schizophrenia (3), and there has been little or no progress in decreasing the mortality gap (2, 4, 5).
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Sep 14, 2023 | 
nature.com | Shahram Bahrami |Oleksandr Frei |Guy Hindley |Anders M. Dale |Srdjan Djurovic |Sigrun Hope
AbstractAutism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)), and risk loci jointly associated with ASD and the cognitive traits. We analyzed data from genome-wide association studies (GWAS) of INT (n = 269,867), EDU (n = 766,345) and ASD (cases n = 18,381, controls n = 27,969).
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Sep 1, 2023 | 
nature.com | Shahram Bahrami |Guy Hindley |Olav B. Smeland |Oleksandr Frei |Chun C. Fan |Srdjan Djurovic | +2 more
AbstractAnorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits have been reported, their shared genetic architecture is largely understudied.
