Christine Liu

Boston

Writer, Designer and Consultant at Freelance

thinker, content wrangler, semi-pro pickle eater. been known to innovate, advocate, indie game. hobbies include thomas hardy, olympic weightlifting, good soup.

Articles

Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain

1 week ago | jneurosci.org | Juliet Nicodemus |Christine Liu |Valerie Tan |William J. Romanow

Human postmortem brain tissuesFrozen human brain tissue samples from Brodmann area (BA) 8/9 (prefrontal cortex, PFC) and BA 21 (medial temporal gyrus, MTG) were obtained from multiple brain banks and stored at −80°C. Brain bank tissues sources included: Dalhousie, Emory University, Neurobiobank (Sepulveda), Southwest Dementia Brain Bank, University of California San Diego ADRC, and Washington University.
Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer’s disease brain

1 month ago | jneurosci.org | Christine Liu |Valerie Tan |William J. Romanow |Juliet Nicodemus

AbstractReverse transcriptase (RT) activity in the human brain has been inferred through somatic retroinsertion/retrotransposition events, however actual endogenous enzymatic activities and sources remain unclear. L1 (LINE-1) retrotransposons bicistronically express ORF2, containing RT and endonuclease (EN) domains, and RNA binding protein ORF1, together enabling L1 retrotransposition and contributing to somatic genomic mosaicism (SGM).
A multi-institutional investigation of psilocybin's effects on mouse behavior

2 months ago | biorxiv.org | Katrina White |Kendall Raymond |Christine Liu |Odilia D Lu

AbstractStudies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, weimplemented a multi-institutional collaborative approach to define the robust and replicable effectsof the psychedelic drug psilocybin on mouse behavior.
Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

Mar 29, 2025 | onlinelibrary.wiley.com | Christine Liu |Jakob Fischer |Michelle Lee |Jess C. Mace

1 Introduction Chronic rhinosinusitis (CRS) is common in people with cystic fibrosis (PwCF), with the majority of adults with CF presenting with radiologic sinus inflammation and sinonasal symptoms [1, 2]. Olfactory dysfunction (OD) is a cardinal symptom of CRS, a commonly reported sequela of sinus disease, and up to 90% of adults with CF may have OD [3, 4].
Scientists discover why obesity takes away the pleasure of eating

Mar 26, 2025 | news.berkeley.edu | Robert Sanders |Christine Liu

The pleasure we get from eating junk food — the dopamine rush from crunching down on salty, greasy French fries and a luscious burger — is often blamed as the cause of overeating and rising obesity rates in our society. But a new study by scientists at the University of California, Berkeley, suggests that pleasure in eating, even eating junk food, is key for maintaining a healthy weight in a society that abounds with cheap, high-fat food.
Navigating China's Healthcare Compliance Landscape: New Guidelines to Mitigate Commercial Bribery Risks | JD Supra

Dec 23, 2024 | jdsupra.com | Christine Liu

China's State Administration for Market Regulation (SAMR) has released the draft Compliance Guidelines for Healthcare Companies to Prevent Commercial Bribery Risks (Draft Guidelines) for public comment. The Draft Guidelines, issued on October 11, 2024, set out the regulator's expectation on how pharmaceutical and medical device companies operating in China may reduce or prevent commercial bribery risks.
RNA Isoform Diversity in Human Neurodegenerative Diseases

Dec 1, 2024 | eneuro.org | Christine Liu |Chris Park |Tony Ngo |William J. Romanow

Human brain tissueControl selection was based on the absence of neuropathology relevant to any of the three diseases and RNA integrity number (RIN) ≥ 6. Disease cases were chosen based on neuropathological confirmation of disease and RIN ≥ 6. Controls: 2 male, 3 female; AD: 4 male, 2 female; PD: 4 male, 3 female; DLB: 4 male, 3 female. Fresh frozen brain tissues from the prefrontal cortex (BA 8/9) were obtained from multiple brain banks (Extended Data Table 1-1) and stored at −80°C.
Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study

Sep 26, 2024 | journals.plos.org | Christine Liu |Jakob Fischer |Jeremiah A. Alt |Todd E. Bodner

Citation: Liu CM, Fischer JL, Alt JA, Bodner TE, Chowdhury NI, Getz AE, et al. (2024) Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study. PLoS ONE 19(9): e0310986.
Primary auditory thalamus relays directly to cortical layer 1 interneurons

Jul 18, 2024 | biorxiv.org | Lucas G. Vattino |Christine Liu |Carolyn G. Sweeney |Cathryn P MacGregror

AbstractInhibitory interneurons within cortical layer 1 (L1-INs) integrate inputs from diverse brain regions to modulate sensory processing and plasticity, but the sensory inputs that recruit these interneurons have not been identified. Here we used monosynaptic retrograde tracing and whole-cell electrophysiology to characterize the thalamic inputs onto two major subpopulations of L1-INs in the mouse auditory cortex.
In Response to Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis

Jun 22, 2024 | onlinelibrary.wiley.com | Christine Liu |Jonathan B. Overdevest |Anna C. Zemke |Jess C. Mace

No abstract is available for this article. BIBLIOGRAPHY 1, , , et al. Predictors of sinonasal improvement after highly effective modulator therapy in adults with cystic fibrosis. Laryngoscope. 2024. https://doi.org/10.1002/lary.31438. 2, , , et al. Elexacaftor-tezacaftor-ivacaftor improves sinonasal outcomes in cystic fibrosis. J Cyst Fibros. 2022; 21(5): 792-799. https://doi.org/10.1016/j.jcf.2022.03.002. 3, , , et al.

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Christine Liu

Articles

Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain

Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer’s disease brain

A multi-institutional investigation of psilocybin's effects on mouse behavior

Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

Scientists discover why obesity takes away the pleasure of eating

Navigating China's Healthcare Compliance Landscape: New Guidelines to Mitigate Commercial Bribery Risks | JD Supra

RNA Isoform Diversity in Human Neurodegenerative Diseases

Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study

Primary auditory thalamus relays directly to cortical layer 1 interneurons

In Response to Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis

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