Christopher E. Mason

New York

Professor of Genomics, Physiology, & Biophysics @WeillCornell Medicine. Co-Founder / COI @BiotiaNYC, @UrsaBio & @Onegevity (@thornehealth)

Articles

Methodologies for Mitochondrial Omic Profiling During Spaceflight

Nov 16, 2024 | link.springer.com | Joseph W. Guarnieri |JangKeun Kim |Douglas Wallace |Christopher E. Mason |Masafumi Muratani |Afshin Beheshti

AbstractTo be able to understand how spaceflight can affect human biology, there is a need for maximizing the amount of information that can be obtained from experiments flown to space. Recently there has been an influx of data obtained from astronauts through multi-omics approaches based on both governmental and commercial spaceflight missions. In addition to data from humans, mitochondrial specific data is gathered for other experiments from rodents and other organisms that are flown in space.
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment - Nature Communications

Apr 3, 2024 | nature.com | Jie Li |Christopher R Chin |Cem Meydan |Pedro Farinha |Yiyue Jiang |Martin Rivas | +9 more

AbstractDespite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting as CD8+ T-cell exhaustion and reduced infiltration.
A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection - European Journal of Human Genetics

Nov 7, 2023 | nature.com | S. Narayanan |Victoria Zaksas |Jiwoon Park |Saswati Das |Pedro M. Moraes-Vieira |Christopher E. Mason | +1 more

AbstractCOVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage.
New Book: Prediction and Risk

Sep 1, 2023 | slguardian.org | Igor Tulchinsky Christopher E. Mason |Igor Tulchinsky |Christopher E. Mason

The following excerpts are adapted from the authors’ recent book, The Age of Prediction, published by MIT PressHumanity has entered a new era. We are now living in a world that is increasingly wired by billions of predictive algorithms, a world in which almost everything can be predicted and risk and uncertainty appear to be diminishing in almost all areas of life. We are living longer, thanks to advances in health care and precision medicine.
The anti-democratic consequences of political polling

Aug 23, 2023 | bigthink.com | Igor Tulchinsky |Christopher E. Mason

Adapted from The Age of Prediction: Algorithms, AI, and the Shifting Shadows of Risk by Igor Tulchinsky and Christopher E. Mason. Copyright © 2023 Igor Tulchinsky and Christopher E. Mason. Published by The MIT Press. Reprinted with permission. Some critics have long viewed polling as an attack on democracy, potentially poisoning that source of democratic legitimacy, voting. In 1996, a journalist named Daniel S.
The Age of Prediction

Aug 22, 2023 | mitpress.mit.edu | Igor Tulchinsky |Christopher E. Mason

Description Praise The power of the ever-increasing tools and algorithms for prediction and their paradoxical effects on risk. The Age of Prediction is about two powerful, and symbiotic, trends: the rapid development and use of artificial intelligence and big data to enhance prediction, as well as the often paradoxical effects of these better predictions on our understanding of risk and the ways we live.
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution - Nature Communications

May 9, 2023 | nature.com | Shicong Du |Christopher E. Mason

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models

May 1, 2023 | jci.org | Anthony T. Reder |Yinghua Ma |Christopher E. Mason |Timothy Vartanian

AbstractMultiple sclerosis (MS) is an inflammatory disease of the CNS. In this issue of the JCI, Ma and Sannino et al. show that two strains of intestinal Clostridium perfringens, known to produce epsilon toxin (ETX), were frequently found in patients with MS. Tiny amounts of this toxin added to immunization with myelin antigens provoked MS-like brain lesions in mice. The distribution of these lesions was diffuse, as in MS, in contrast to the spinal cord–restricted lesions of most animal models.
To Mars and Beyond: Engineering Life as a Moral Duty

Apr 18, 2023 | liebertpub.com | Christopher E. Mason |To Mars

GEN BiotechnologyVol. 2, No. 2CommentaryFree AccessThe Martian may not be science fiction much longer, writes the author of The Next 500 Years. The Polaris Dawn mission from SpaceX is set to launch this summer, and it will include some crew members who will also be taking the SpaceX Starship on its first mission in the next year or two in space. This is significant, as the Starship will likely be the first spacecraft to take humans back to the moon and then to the red planet.
Biomonitoring and precision health in deep space supported by artificial intelligence - Nature Machine Intelligence

Mar 23, 2023 | nature.com | Ryan Scott |Lauren Sanders |Erik L. Antonsen |Seung-min Park |Robert Reynolds |Casey Greene | +18 more

AbstractHuman exploration of deep space will involve missions of substantial distance and duration. To effectively mitigate health hazards, paradigm shifts in astronaut health systems are necessary to enable Earth-independent healthcare, rather than Earth-reliant. Here we present a summary of decadal recommendations from a workshop organized by NASA on artificial intelligence, machine learning and modelling applications that offer key solutions toward these space health challenges.

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Chris Mason @mason_lab

18 Apr 25

RT @SpaceLuisZea: Funding opportunity for space R&D in Central America

Chris Mason @mason_lab

17 Apr 25

RT @Chandrima_04: The Gowanus Canal in Brooklyn is an Superfund site which contains significant amounts of chemicals but we see the microbe…

Chris Mason @mason_lab

16 Apr 25

Our new paper with @nyuniversity and Elizabeth Henaff! "Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential" https://t.co/BZvLp0s3pE

Christopher E. Mason

Articles

Methodologies for Mitochondrial Omic Profiling During Spaceflight

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment - Nature Communications

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection - European Journal of Human Genetics

New Book: Prediction and Risk

The anti-democratic consequences of political polling

The Age of Prediction

Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution - Nature Communications

Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models

To Mars and Beyond: Engineering Life as a Moral Duty

Biomonitoring and precision health in deep space supported by artificial intelligence - Nature Machine Intelligence

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Emails

Socials & Sites

X (formerly Twitter)