Victoria Zaksas

Oct 22, 2024 | nature.com | Diego Galeano |Victoria Zaksas |Stephen B. Baylin |Douglas C. Wallace |Frank J. Slack |Francisco J. Enguita | +1 more

AbstractMicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases. Yet, predicting small molecules associated with miRNAs remains challenging due to the small size of small molecule-miRNA datasets.

Oct 22, 2024 | flipboard.com | Diego Galeano |Jeffrey Haltom |Chaylen Andolino |Aliza Yousey |Victoria Zaksas |Saswati Das | +9 more

MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small …

Jun 10, 2024 | nature.com | JangKeun Kim |Nídia S. Trovão |Keith Siew |Jiwoon Park |Eliah G. Overbey |Francisco J. Enguita | +12 more

AbstractOur previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this work to determine the biological factors rescued by the countermeasure treatment.

Jun 10, 2024 | nature.com | Begum Mathyk |Marshall Tabetah |Rashid Karim |Victoria Zaksas |JangKeun Kim |Jiwoon Park | +6 more

AbstractOrganismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here, we extend molecular work to energy metabolism and sex hormone signaling in mice and humans. We found spaceflight induced changes in insulin and estrogen signaling in rodents and humans.

Nov 7, 2023 | nature.com | S. Narayanan |Victoria Zaksas |Jiwoon Park |Saswati Das |Pedro M. Moraes-Vieira |Christopher E. Mason | +1 more

AbstractCOVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage.