Christos Pantelis

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Articles

Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies | Translational Psychiatry

Dec 1, 2023 | nature.com | Celso Arango |Richard Dinga |Birte Glenthøj |René S. Kahn |Robin Murray |Carmine Pariante | +2 more

AbstractThere is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals.
Effects of risperidone/paliperidone versus placebo on cognitive functioning over the first 6 months of treatment for psychotic disorder: secondary analysis of a triple-blind randomised clinical trial | Translational Psychiatry

Jun 10, 2023 | nature.com | Kelly Allott |Aswin Ratheesh |Christos Pantelis |Shona M. Francey

AbstractThe drivers of cognitive change following first-episode psychosis remain poorly understood. Evidence regarding the role of antipsychotic medication is primarily based on naturalistic studies or clinical trials without a placebo arm, making it difficult to disentangle illness from medication effects.

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