Christos Pantelis

Dec 1, 2023 | nature.com | Celso Arango |Richard Dinga |Birte Glenthøj |René S. Kahn |Robin Murray |Carmine Pariante | +2 more

AbstractThere is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals.

Jun 10, 2023 | nature.com | Kelly Allott |Aswin Ratheesh |Christos Pantelis |Shona M. Francey

AbstractThe drivers of cognitive change following first-episode psychosis remain poorly understood. Evidence regarding the role of antipsychotic medication is primarily based on naturalistic studies or clinical trials without a placebo arm, making it difficult to disentangle illness from medication effects.

May 5, 2023 | nature.com | Dominic B. Dwyer |Alessandro Pigoni |Junhao Wen |Gyujoon Hwang |Guray Erus |René S. Kahn | +11 more

AbstractUsing machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a ‘lower brain volume’ subgroup (SG1) and an ‘higher striatal volume’ subgroup (SG2) with otherwise normal brain structure.