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Aug 1, 2024 | 
digitalcommons.library.tmc.edu | Christopher Jones |Eliah G. Overbey |Jerome Lacombe |Adrian J Ecker
Keywords Adult, Female, Humans, Male, Astronauts, Cognition, Space Flight, Stress, Physiological, Time Factors, Weightlessness, Monitoring, Physiologic, Multiomics, Adaptation, Physiological, Databases as Topic, Physiology, Molecular biology, Cognitive neuroscience, Oculomotor system, Visual system Abstract Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight to a broader...
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Jul 22, 2024 | 
nature.com | Lindsay Rutter |Henry Cope |Nathaniel J. Szewczyk |JangKeun Kim |Eliah G. Overbey |Braden T. Tierney | +4 more
AbstractCommon and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health.
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Jun 11, 2024 | 
nature.com | Henry Cope |Jonas Elsborg |Samuel Demharter |J. McDonald |Chiara Wernecke |Sigrid S. Reinsch | +11 more
AbstractSpaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood.
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Jun 11, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more
AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
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Jun 11, 2024 | 
nature.com | Christopher Jones |Eliah G. Overbey |Cem Meydan |Braden T. Tierney |Jiwoon Park |Theodore Nelson | +14 more
AbstractHuman spaceflight has historically been managed by government agencies, such as in the NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight to a broader population.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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Jun 11, 2024 | 
nature.com | JangKeun Kim |Eliah G. Overbey |Richa Batra |Annalise Schweickart |Deena Najjar |Cem Meydan | +6 more
AbstractAs spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins.
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Jun 10, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Remi Klotz |Irina Matei |Bader Shirah | +2 more
AbstractThe SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022.
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Jun 10, 2024 | 
nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more
AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
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Jun 10, 2024 | 
nature.com | Fei Wu |JangKeun Kim |Eliah G. Overbey |Cem Meydan |Christopher Mason
AbstractTelomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths that contributes to end-capping structure and function, and facilitates telomeric recombination in tumors that maintain telomere length via the telomerase-independent Alternative Lengthening of Telomeres (ALT) pathway.
