Douglas C. Wallace

Oct 22, 2024 | nature.com | Diego Galeano |Victoria Zaksas |Stephen B. Baylin |Douglas C. Wallace |Frank J. Slack |Francisco J. Enguita | +1 more

AbstractMicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases. Yet, predicting small molecules associated with miRNAs remains challenging due to the small size of small molecule-miRNA datasets.

Jun 10, 2024 | nature.com | Yuvarani Masarapu |Egle Cekanaviciute |Jakub O. Westholm |Asa Bjorklund |Åsa K. Björklund |Pau Badia-i-Mompel | +11 more

AbstractImpairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice.