Frank J. Slack

Oct 22, 2024 | nature.com | Diego Galeano |Victoria Zaksas |Stephen B. Baylin |Douglas C. Wallace |Frank J. Slack |Francisco J. Enguita | +1 more

AbstractMicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases. Yet, predicting small molecules associated with miRNAs remains challenging due to the small size of small molecule-miRNA datasets.

Oct 22, 2024 | flipboard.com | Diego Galeano |Jeffrey Haltom |Chaylen Andolino |Aliza Yousey |Victoria Zaksas |Saswati Das | +9 more

MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small …

Sep 13, 2024 | onlinelibrary.wiley.com | Alice Rodrigues |Yujing J. Heng |Frank J. Slack

Acaca acetyl-Coenzyme A carboxylase alpha AKT activates protein kinase B ALT alanine aminotransferases AST aspartate aminotransferases AUC Area under the curve CD81 CD81 antigen CD9 CD9 antigen CEBPA/Cebpa CCAAT enhancer binding protein alpha Cs citrate synthase Dgat1 diacylglycerol O-acyltransferase 1 EGFR Epidermal growth factor receptor EV extracellular vesicles EV-A extracellular vesicles from aged mice EV-C extracellular vesicles from young mice EV-EX extracellular vesicles from young...

Sep 4, 2024 | nature.com | Frank J. Slack

AbstractInteractions between tumor and stromal cells are well known to play prominent roles in progression of pancreatic ductal adenocarcinoma (PDAC). As knowledge of stromal crosstalk in PDAC has evolved, it has become clear that cancer associated fibroblasts can play both tumor promoting and tumor suppressive roles through a combination of paracrine crosstalk and juxtacrine interactions involving direct physical contact.

May 21, 2024 | nature.com | Yered Pita-Juarez |Felipe Batalini |Shivani Nanda |Frank J. Slack |Xanthi-Lida Katopodi |Eleni Kanata | +2 more

AbstractThe landscape of non-coding mutations in cancer progression and immune evasion is largely unexplored. Here, we identify transcrptome-wide somatic and germline 3′ untranslated region (3′-UTR) variants from 375 gastric cancer patients from The Cancer Genome Atlas.