Stephen B. Baylin

Oct 22, 2024 | nature.com | Diego Galeano |Victoria Zaksas |Stephen B. Baylin |Douglas C. Wallace |Frank J. Slack |Francisco J. Enguita | +1 more

AbstractMicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases. Yet, predicting small molecules associated with miRNAs remains challenging due to the small size of small molecule-miRNA datasets.

Oct 22, 2024 | flipboard.com | Diego Galeano |Jeffrey Haltom |Chaylen Andolino |Aliza Yousey |Victoria Zaksas |Saswati Das | +9 more

MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small …

Jun 10, 2024 | nature.com | JangKeun Kim |Nídia S. Trovão |Keith Siew |Jiwoon Park |Eliah G. Overbey |Francisco J. Enguita | +12 more

AbstractOur previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this work to determine the biological factors rescued by the countermeasure treatment.

Jul 24, 2023 | pnas.org | Stephen B. Baylin |Damon Centola |Joshua Becker |Jingwen Zhang

M. Toyota et al., CpG island methylator phenotype in colorectal cancer. Proc. Natl. Acad. Sci. U.S.A. 96, 8681–8696 (1999). M. P. Hanley et al., Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia. Oncogene 36, 5035–5044 (2017). C. Liu et al., DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas. Clin. Epigenetics 11, 90 (2019). S. Yang, F. A. Farraye, C. Mack, O. Posnik, M. J.

Apr 26, 2023 | futuremedicine.com | Stephen B. Baylin

EpigenomicsAhead of PrintInterviewFree AccessInterviewerHello, Stephen, thank you for agreeing to do the interview for Epigenomics. I have prepared a few questions that I would like to ask you for the journal's audience. Stephen BaylinSure. InterviewerCould you please introduce yourself and briefly describe your research focus?