Drew Weissman

Nov 21, 2024 | nature.com | Xuexiang Han |Mohamad-Gabriel Alameh |Rakan El-Mayta |Kelsey Swingle |Junchao Xu |Ningqiang Gong | +5 more

AbstractIonizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the development of potent and biodegradable ionizable lipids, yet methodologies for the stepwise optimization of ionizable lipid structure are lacking.

Jul 9, 2024 | nature.com | Xuexiang Han |Ningqiang Gong |Lulu Xue |Majed Ghattas |Junchao Xu |Gan Zhao | +8 more

AbstractLipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly affecting biodistribution, cellular uptake, endosomal escape and transfection efficiency. However, the laborious synthesis of cationic lipids limits the discovery of efficacious candidates and slows down scale-up manufacturing.

Jun 14, 2024 | portside.org | Drew Weissman

Messenger RNA Therapies Are Finally Fulfilling Their Promise Published June 14, 2024 Editor’s Note (10/2/23): Katalin Karikó and Drew Weissman were awarded the 2023 Nobel Prize in Physiology or Medicine for their work on mRNA, which led to COVID vaccines that have protected billions of people. Weissman describes the promise of mRNA therapies in this 2022 feature. In just 17 years, messenger RNA therapies went from proof of concept to global salvation.

Oct 2, 2023 | techcentral.co.za | Katalin Karikó |Drew Weissman

Hungarian scientist Katalin Karikó and US colleague Drew Weissman, who met in line for a photocopier before making mRNA molecule discoveries together that paved the way for Covid-19 vaccines, won the 2023 Nobel Prize for Medicine on Monday. “The laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times,” the Swedish award-giving body said in the latest accolade for the pair.

Oct 2, 2023 | gulfnews.com | Jay Hilotin |Vijith Pulikkal |Drew Weissman

Miraculously, he solved that problem together with a colleague, with a bit of clever biochemistry. The breakthrough came in 2005, when Weismann met Hungarian biochemist Katalin Karikó at the University of Pennsylvania (Penn). On Tuesday (October 2, 2023), Dr Weissman, alongside researcher Dr Karikó, were name Nobel laureates in medicine for ushering in the development of mRNA vaccines.