Elisenda Bueichekú

Jun 6, 2024 | nature.com | Ibai Diez |Mark Albers |William Orwig |Elisenda Bueichekú |Jonas Olofsson |Patrizia Vannini | +1 more

AbstractThe direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD).

Apr 24, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Reisa Sperling |Jorge Sepulcre

AbstractAutopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By combining in vivo longitudinal magnetic resonance imaging measures of LC integrity, tau positron emission tomography imaging and cognition with autopsy data and transcriptomic information, we examined whether LC changes precede allocortical tau deposition and whether specific genetic features underlie LC’s selective vulnerability to tau.

Apr 5, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Geoffroy Gagliardi |Kayden J. Mimmack |Jorge Sepulcre

AbstractUnawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer’s Disease (AD), unawareness may develop in predementia stages and contributes to disease severity and progression. Here, we use in-vivo multi-modal neuroimaging to profile the brain phenotype of individuals presenting altered self-awareness of memory during aging.