Reisa Sperling

Sep 20, 2024 | nature.com | Shannon L. Risacher |Paula J Bice |Jared Brosch |Kelley Faber |Martin R Farlow |Tatiana Foroud | +29 more

AbstractDetermining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron emission tomography in 3046 participants from 12 independent studies. The CYP1B1-RMDN2 locus is associated with tau deposition.

Jul 18, 2024 | nature.com | Juan Fortea |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla |Marc Suárez-Calvet | +4 more

replying to C. Pappalettera et al. Nat. Med. https://doi.org/10.1038/s41591-024-03158-5 (2024)Pappalettera et al.1 raise important points concerning our recent publication on APOE4 homozygotes2, specifically about the definition of Alzheimer’s disease (AD), resilience factors, and the ethical implications of diagnosing asymptomatic individuals.

Jun 17, 2024 | nature.com | Juan Fortea |Jordi Pegueroles |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla | +5 more

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-02931-w, published online 6 May 2024In the version of the article initially published, the title of Fig. 4 read “APOE3 homozygotes” and has now been amended to “APOE4 homozygotes” in the HTML and PDF versions of the article. About this articleFortea, J., Pegueroles, J., Alcolea, D. et al. Publisher Correction: APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease. Nat Med (2024).

Jun 6, 2024 | nature.com | Ibai Diez |Mark Albers |William Orwig |Elisenda Bueichekú |Jonas Olofsson |Patrizia Vannini | +1 more

AbstractThe direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD).

May 6, 2024 | nature.com | Juan Fortea |Jordi Pegueroles |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla | +5 more

AbstractThis study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis included 3,297 individuals for the pathological study and 10,039 for the clinical study.