Jorge Sepulcre

Apr 29, 2024 | biologicalpsychiatryjournal.com | Alexandra O'Neill |Jorge Sepulcre |Melissa Pax

Cognitive deficits in psychotic disorders are debilitating, treatment-resistant and predict long-term functional outcomes. It is important to characterize and predict such deficits in the early phase of illness, where treatments may be more effective. In this study, we aimed to predict cognitive functioning in individual patients with early psychosis using connectome-based predictive models (CPMs) and identify clinical and sociodemographic factors that may affect prediction accuracy.

Apr 24, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Reisa Sperling |Jorge Sepulcre

AbstractAutopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By combining in vivo longitudinal magnetic resonance imaging measures of LC integrity, tau positron emission tomography imaging and cognition with autopsy data and transcriptomic information, we examined whether LC changes precede allocortical tau deposition and whether specific genetic features underlie LC’s selective vulnerability to tau.

Apr 5, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Geoffroy Gagliardi |Kayden J. Mimmack |Jorge Sepulcre

AbstractUnawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer’s Disease (AD), unawareness may develop in predementia stages and contributes to disease severity and progression. Here, we use in-vivo multi-modal neuroimaging to profile the brain phenotype of individuals presenting altered self-awareness of memory during aging.

Feb 14, 2024 | jneurosci.org | Victor Montal |Jorge Sepulcre

Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging Chan-Mi Kim, Ibai Diez, Elisenda Bueichekú, Sung Ahn, Victor Montal, Jorge Sepulcre Journal of Neuroscience 14 February 2024, 44 (7) e0488232023; DOI: 10.1523/JNEUROSCI.0488-23.2023

Dec 14, 2023 | jneurosci.org | Victor Montal |Jorge Sepulcre

Spatiotemporal correlation between amyloid and tau accumulations underlies cognitive changes in aging Chan-Mi Kim, Ibai Diez, Elisenda Bueichekú, Sung Ahn, Victor Montal, Jorge Sepulcre Journal of Neuroscience 20 December 2023, JN-RM-0488-23; DOI: 10.1523/JNEUROSCI.0488-23.2023