Ibai Diez

Jun 6, 2024 | nature.com | Ibai Diez |Mark Albers |William Orwig |Elisenda Bueichekú |Jonas Olofsson |Patrizia Vannini | +1 more

AbstractThe direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD).

Apr 24, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Reisa Sperling |Jorge Sepulcre

AbstractAutopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By combining in vivo longitudinal magnetic resonance imaging measures of LC integrity, tau positron emission tomography imaging and cognition with autopsy data and transcriptomic information, we examined whether LC changes precede allocortical tau deposition and whether specific genetic features underlie LC’s selective vulnerability to tau.

Apr 5, 2024 | nature.com | Elisenda Bueichekú |Ibai Diez |Geoffroy Gagliardi |Kayden J. Mimmack |Jorge Sepulcre

AbstractUnawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer’s Disease (AD), unawareness may develop in predementia stages and contributes to disease severity and progression. Here, we use in-vivo multi-modal neuroimaging to profile the brain phenotype of individuals presenting altered self-awareness of memory during aging.

Mar 14, 2024 | medrxiv.org | Petr Sojka |Tereza Serranová |David Perez |David Pérez |Ibai Diez

P. Sojka reports no disclosures relevant to the manuscript; T. Serranova reports no disclosures relevant to the manuscript; S.S. Khalsa is on the editorial board of Biological Psychology, has performed scientific consultation for Janssen, is supported by funding from the NIH and The William K.

Feb 28, 2024 | nature.com | Ibai Diez |Asier Erramuzpe

AbstractThe human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connections is critical to advancing our comprehension of brain function and disorders. However, accurately predicting structural connectivity from its functional counterpart remains a challenging pursuit.