Eric Hanssen

Nov 19, 2023 | nature.com | Eric Hanssen |Craig Morton |Michael Parker |Paul Gooley |Clara C. Kosasih

AbstractInterleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into current inhibitors are lacking. Here we present cryo-EM and crystal structures of the human IL-11 signalling complex, including the complex containing the complete extracellular domains of the shared IL-6 family β-receptor, gp130.

Aug 15, 2023 | biorxiv.org | Hamish Brown |Dan Smith |Eric Hanssen |Benjamin C Wardle

New Results doi: https://doi.org/10.1101/2023.08.13.553155 AbstractIn transmission electron microscopy (TEM) cameras are square or rectangular but beams are round. With a beam size chosen to fill the camera at a given image magnification, the circular lobes of the beam will extend beyond the camera's field of view and irradiate areas that are not acquired on the camera, damaging and precluding them from future acquisitions if the sample is beam sensitive.