Ertan Mayatepek

Aug 22, 2024 | nature.com | Selene Lickfett |Agnieszka Rybak-Wolf |Carmen Menacho |Stephanie Le |Tancredi Massimo Pentimalli |Daniel Oehler | +14 more

AbstractExpansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we engineered male induced pluripotent stem cells to introduce a biallelic or monoallelic mutant 70Q expansion or to remove the poly-Q tract of HTT.

May 22, 2024 | onlinelibrary.wiley.com | Ju-Young Kim |Ertan Mayatepek |Marc Jacobsen |Julia Seyfarth

INTRODUCTION Common-γ cytokines are named after the γc chain receptor chain (CD132) that is part of all receptor complexes in this family. γc cytokines fulfil various functions in the immune system and, especially, T-cell activation and differentiation depend on γc cytokines (mainly IL-2 and IL-7) [1]. IL-2 provides the crucial third signal during T-cell activation promoting proliferation and differentiation of naïve T cells towards effector T cells.