Evan K. Irving-Pease

Jan 10, 2024 | nature.com | Evan K. Irving-Pease |Anders Fischer |Karl-Göran Sjögren |Alma Halgren |Ruairidh Macleod |Rasmus Henriksen | +14 more

AbstractThe Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia.

Jan 10, 2024 | nature.com | Yaoling Yang |Evan K. Irving-Pease |Kathrine E. Attfield |Gabriele Scorrano |Thorfinn Sand Korneliussen |Martin Sikora | +3 more

AbstractMultiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1.

Jan 4, 2024 | nature.com | Evan K. Irving-Pease

Most autoimmune diseases are caused by the interplay between common genetic risk variants and environmental factors. New studies of ancient genomes suggest that many of these variants evolved under strong selection pressures, probably due to lifestyle-specific environmental pathogens, the consequences of which shape the distribution of present-day disease risk and point to novel therapeutic interventions.