Fabian J. Theis

Jan 22, 2025 | nature.com | Fabian J. Theis

Aug 22, 2024 | nature.com | Qing Nie |Fabian J. Theis

AbstractOver the last decade, biology has begun utilizing ‘big data’ approaches, resulting in large, comprehensive atlases in modalities ranging from transcriptomics to neural connectomics. However, these approaches must be complemented and integrated with ‘small data’ approaches to efficiently utilize data from individual labs.

Jul 10, 2024 | nature.com | Sainitin Donakonda |Jitao Zhang |Hannah Wintersteller |Martin Feuerherd |Juliane Siebourg-Polster |Carolin Mogler | +24 more

AbstractChronic hepatitis B virus (HBV) infection affects 300 million patients worldwide1,2, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes3,4,5,6,7. Here we demonstrate that a liver immune rheostat renders virus-specific CD8 T cells refractory to activation and leads to their loss of effector functions.

Nov 22, 2023 | nature.com | Sebastian Schmidt |Duc Vu |Martin Regensburger |Ozge Karayel |Dietrich Trümbach |Martin Jastroch | +7 more

AbstractSporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor cells and dopaminergic neurons derived from induced pluripotent stem cells (hiPSCs) from sPD patients exhibited a hypometabolism.

Aug 17, 2023 | cell.com | Mohammad Lotfollahi |Fabian J. Theis |Rahul Satija

GlossaryMultimodal reference: a reference atlas that is built using more than one modality (for example, RNA and ATAC). Multimodal omics: technologies capable of capturing multiple data types from the same sample. Supervised vs. unsupervised learning: in this context, data integration while leveraging cell-type labels in the reference and query dataset (supervised) compared with the scenario in which the method has no access to these labels (unsupervised).