Fan Fan

Nov 11, 2024 | biorxiv.org | Fan Fan |Xianghu Meng |Han Wang |Bowen Zhang

AbstractRecent advancements in artificial intelligence (AI) have revolutionized the field of 3D molecule generation. However, the lack of effective evaluation methods for 3D conformations limits further improvements.

Sep 6, 2024 | biorxiv.org | Susmita Ghosh |Fan Fan |Reid T. Powell |Yong D. Park

AbstractBackground: KRAS is frequently mutated in the tumors of patients with metastatic colorectal cancer (mCRC) and thus represents a valid target for therapy. However, the strategies of targeting KRAS directly and targeting the downstream effector mitogen-activated protein kinase kinase (MEK) via monotherapies have shown limited efficacy. Thus, there is a strong need for novel, effective combination therapies to improve MEK-inhibitor efficacy in patients with KRAS-mutated mCRC.

Aug 28, 2024 | digitalcommons.library.tmc.edu | Fan Fan |Susmita Ghosh |Reid T. Powell |Jason Roszik

AbstractMetastatic colorectal cancer (mCRC) is the second leading cause of cancer deaths in the United States. More than 50% of patients with mCRC harbor mutations of the oncogenic driver RAS (KRAS or NRAS). Because directly targeting most mutations of RAS is technically challenging, researchers have concentrated on targeting MEK, a downstream mediator of RAS. However, targeting MEK as single-agent therapy is ineffective in patients with mCRC.

Jul 5, 2024 | pubs.rsc.org | Jiaying Zhang |Fan Fan |Wei Zhu

Oxygen defect regulation and photocatalytic-peroxymonosulfate activation of Co(ii)/BiPO4−x composites synergistically promoting medical waste degradation† The low regeneration rate of Co(II) is a major obstacle to the efficient activation of peroxymonosulfate (PMS) by Co in advanced oxidation technology. Herein, a Co(II)/oxygen-defect monoclinic monazite BiPO4 (Co(II)/BiPO4−x) photocatalyst was prepared.

Jun 27, 2024 | chine.in | Liang Yunfang |Yao Yuan |Fan Fan

L'eau du lac Poyang, le plus grand lac d'eau douce de Chine, a dépassé jeudi matin le niveau d'alerte, en raison des fortes pluies qui ont frappé de vastes régions de la Chine. Le niveau d'eau à la station hydrologique de Xingzi du lac a atteint 19,03 mètres vers 07H00, dépassant le niveau d'alerte de 19 mètres. Le lac, situé dans la province orientale du Jiangxi, sert de réservoir naturel important le long du Yangtsé, le plus grand fleuve de Chine.