Feixiong Cheng

Oct 24, 2024 | nature.com | Yunguang Qiu |Mateo Torres |Weiqiang Lu |Siqi Liang |Charis Eng |Joseph Loscalzo | +1 more

AbstractTo assist the translation of genetic findings to disease pathobiology and therapeutics discovery, we present an ensemble deep learning framework, termed PIONEER (Protein–protein InteractiOn iNtErfacE pRediction), that predicts protein-binding partner-specific interfaces for all known protein interactions in humans and seven other common model organisms to generate comprehensive structurally informed protein interactomes.

Jul 23, 2024 | biorxiv.org | Yuxin Yang |Feixiong Cheng |Kingsten Lin

AbstractThe continued growth of antibiotic resistance and the slowing of antibiotic discovery poses a large challenge in fighting infectious diseases. Recent advances in Artificial intelligence (AI) technologies offer a time- and cost-effective solution for the rapid development of effective antibiotics. In this study, we presented an explainable AI framework from a pre-trained model using 10 million drug-like molecular images.

Feb 20, 2024 | cell.com | Feixiong Cheng |Fei Wang |Jian Tang

SummaryThe high failure rate of clinical trials in Alzheimer’s disease (AD) and AD-related dementia (ADRD) is due to a lack of understanding of the pathophysiology of disease, and this deficit may be addressed by applying artificial intelligence (AI) to “big data” to rapidly and effectively expand therapeutic development efforts.

Dec 15, 2023 | neurologylive.com | Feixiong Cheng

WATCH TIME: 3 minutes"The inflammation profile in a male and female may be different. In multiple disease like heart disease and cancer, people see more inflammation and key cytokine expression in women compared with men."As clinicians continue to uncover more about the pathology of Alzheimer disease (AD), research has shown that the disease disproportionately affects women.

May 11, 2023 | nature.com | Adam Lauko |Karl Johan Tronstad |Daniel Silver |Gauravi Deshpande |Joris Guyon |Laura Neises | +10 more

Ethics statementsHuman material was obtained from surgeries performed at the Haukeland University Hospital (Bergen, Norway). Written consent was obtained from individuals with procedures that were approved for the projects (project numbers 013.09 and 151825) by the Regional Ethical Committee. Animal experiments were approved by the Institutional Animal Care and Use Committee of Cleveland Clinic and local ethical committee. Animals were treated in accordance with the Norwegian Animal Act.