Hang Liu

Nov 26, 2024 | mdpi.com | Hang Liu |Lin Wang |Chen Yao

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Nov 9, 2024 | nature.com | Jun Tao |Wen Dai |Hang Liu |Juan Le |Ting Sun |Qian Yao | +4 more

Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further.

Sep 9, 2024 | onlinelibrary.wiley.com | Yuxin Gao |Engineering Huazhong |Hang Liu |Xintian Tina Wang

Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.

Jul 15, 2024 | link.aps.org | Hang Liu |Tianjin Normal |Hong Guo

It was recently found that the optical field fluctuations in self-defocusing media can be described by sound waves propagating in a two-dimensional photon fluid. This photon fluid is controlled by the driving beam and serves as the background in which the sound waves can experience an effective curved spacetime, such that it provides a new platform of studying analog black holes.

Jul 5, 2024 | mdpi.com | Hang Liu |Fan Wu |Siying S. Li |Haiting Zhang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.