Wen Dai

Nov 12, 2024 | onlinelibrary.wiley.com | Hao Zang |Dong Wang |Wen Dai |Lin Chen

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202407321-sup-0001-SuppMat.docx2.9 MB Supporting Information References 1, , , , , , , J. Am. Chem. Soc. 2023, 145, 20897. 2, , , , , , , , , J. Nanobiotechnol. 2021, 19, 12. 3, , , , , , Anal. Chem. 2024, 96, 6652. 4, , , , , , Sens. Actuators, B 2022, 357, 131408. 5a) , , , , , , Nano Res. 2024, 17, 7926; b) , , , , , , Adv. Mater.

Nov 9, 2024 | nature.com | Jun Tao |Wen Dai |Hang Liu |Juan Le |Ting Sun |Qian Yao | +4 more

Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further.

Nov 27, 2023 | mdpi.com | Hong Wei |Wen Dai |Bo Wang |Hui Zhu

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Aug 31, 2023 | science.org | Huy Tran |Huy Trần |Wen Dai |Bei You

Flexible Positive Pressure SensorsTecan has announced the launch of the Resolvex A200 Omics and Resolvex A200 24, the next generation of Resolvex A200 positive pressure processors. The Resolvex A200 is a standalone system for automated positive pressure sample preparation which is designed to address unmet workflow needs by improving the flexibility and efficiency of the sample preparation process.

Aug 31, 2023 | science.org | Huy Tran |Huy Trần |Wen Dai |Bei You |Marc Tessier-Lavigne

On 8 February 2001, Science published the Research Article “Hierarchical organization of guidance receptors: Silencing of netrin attraction by Slit through a Robo/DCC receptor complex” (1).