Hongkui Zeng

1 month ago | cell.com | Yoav Ben-Simon |Marcus J. Hooper |Sujatha Narayan |Tanya L. Daigle |Deepanjali Dwivedi |Sharon Way | +141 more

Keywords epigenetics transcriptomics enhancer cell type neocortex AAV transgenic recombinase mouse human Introduction To understand how the brain works, we need to establish the structure-function relationships between the units that comprise it and the outputs of its activity.1 One approach is to gain experimental access to each building block (e.g., a cell type) and manipulate it to observe effects on an animal’s physiology and behavior.2,3,4 Historically, the definition of building blocks...

Jan 1, 2025 | nature.com | Hongkui Zeng

AbstractBiological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function1,2. Mammalian brains consist of thousands of cell types3, which may be differentially susceptible or resilient to ageing.

Nov 22, 2024 | nature.com | Cory Miller |Xiaoke Chen |Zoe Donaldson |Bianca Jones Marlin |Doris Tsao |Ziv M. Williams | +2 more

Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric disorders. The success of this program is evidenced by the accelerated discoveries and development of interventions that are happening in real time.

Aug 1, 2024 | nature.com | Linus Manubens-Gil |Yufeng Liu |Alessandro Bria |Lei Qu |Lin Gu |Weidong Cai | +20 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-023-01848-5, published online 17 April 2023. In the version of the article initially published, the Acknowledgements did not include thanks to H. Mansvelder (Vrije Universiteit Amsterdam), C. de Kock (Vrije Universiteit Amsterdam), R. Benavides-Piccione and J. DeFelipe (Instituto Cajal - CSIC). Additionally, Supplementary Table 1 has been updated to separate rows 27 and 28.

Jan 24, 2024 | nature.com | Lei Jin |Thomas Lavin |Kelsey R. Babcock |Ming Hu |Hongkui Zeng |Mriganka Sur | +1 more

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-023-01545-8, published online 11 January 2024. In the version of the article initially published, in Figs. 1–6 the minus sign was missing from “Day −7” and has now been inserted in the HTML and PDF versions of the article.