Hongkui Zeng

Jan 1, 2025 | nature.com | Hongkui Zeng

AbstractBiological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function1,2. Mammalian brains consist of thousands of cell types3, which may be differentially susceptible or resilient to ageing.

Nov 22, 2024 | nature.com | Cory Miller |Xiaoke Chen |Zoe Donaldson |Bianca Jones Marlin |Doris Tsao |Ziv M. Williams | +2 more

Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric disorders. The success of this program is evidenced by the accelerated discoveries and development of interventions that are happening in real time.

Aug 1, 2024 | nature.com | Linus Manubens-Gil |Yufeng Liu |Alessandro Bria |Lei Qu |Lin Gu |Weidong Cai | +20 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-023-01848-5, published online 17 April 2023. In the version of the article initially published, the Acknowledgements did not include thanks to H. Mansvelder (Vrije Universiteit Amsterdam), C. de Kock (Vrije Universiteit Amsterdam), R. Benavides-Piccione and J. DeFelipe (Instituto Cajal - CSIC). Additionally, Supplementary Table 1 has been updated to separate rows 27 and 28.

Jan 24, 2024 | nature.com | Lei Jin |Thomas Lavin |Kelsey R. Babcock |Ming Hu |Hongkui Zeng |Mriganka Sur | +1 more

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-023-01545-8, published online 11 January 2024. In the version of the article initially published, in Figs. 1–6 the minus sign was missing from “Day −7” and has now been inserted in the HTML and PDF versions of the article.

Jan 11, 2024 | nature.com | Lei Jin |Thomas Lavin |Kelsey R. Babcock |Ming Hu |Hongkui Zeng |Mriganka Sur | +1 more

AbstractRabies-virus-based monosynaptic tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present a second-generation system for labeling direct inputs to targeted neuronal populations with minimal toxicity, using double-deletion-mutant rabies viruses. Viral spread requires expression of both deleted viral genes in trans in postsynaptic source cells.