-
Dec 2, 2024 | 
journals.plos.org | Meng Yuan |KU Leuven |Hospitals Gasthuisberg Leuven |Seppe Goovaerts
Citation: Yuan M, Goovaerts S, Vanneste M, Matthews H, Hoskens H, Richmond S, et al. (2024) Mapping genes for human face shape: Exploration of univariate phenotyping strategies. PLoS Comput Biol 20(12): e1012617. https://doi.org/10.1371/journal.pcbi.1012617Editor: Xin He, University of Chicago Pritzker School of Medicine, UNITED STATES OF AMERICAReceived: April 7, 2024; Accepted: November 5, 2024; Published: December 2, 2024Copyright: © 2024 Yuan et al.
-
Oct 25, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |Harefield Hospitals
As patients with congenital heart disease (CHD) live longer, non-congenital cardiologists and other healthcare professionals are increasingly confronted with this growing population. However, training regarding this pathology is generally lacking. The lifelong burden of adult CHD (ACHD) care arises from the original nature of the congenital heart defect, complications prior to interventions, consequences of previous interventions, periprocedural complications, and residual lesions.
-
Oct 25, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |Harefield Hospitals
As patients with congenital heart disease (CHD) continue to enjoy longer lives, non-congenital cardiologists and other healthcare professionals are increasingly encountering them in their practice and are challenged by their specific needs. Most under- and post-graduate medical training tends to overlook this common pathology, resulting in insufficient awareness of post-repair or post-palliation residual lesions and sequelae from previous interventions.
-
Sep 17, 2024 | 
journals.plos.org | Seppe Goovaerts |KU Leuven |Hospitals Gasthuisberg Leuven |Myoung Keun Lee
Citation: Goovaerts S, El Sergani AM, Lee MK, Shaffer JR, Claes P, Weinberg SM (2024) The impact of breastfeeding on facial appearance in adolescent children. PLoS ONE 19(9): e0310538. https://doi.org/10.1371/journal.pone.0310538Editor: James J. Cray Jr., Ohio State University, UNITED STATES OF AMERICAReceived: March 14, 2024; Accepted: September 3, 2024; Published: September 17, 2024Copyright: © 2024 Goovaerts et al.
-
Sep 9, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |KU Leuven
Timely and accurate notification of critical results is crucial in laboratory medicine and mandated by accreditation standards like ISO15189. Alert lists do, however, vary widely and clinical laboratories typically rely on a combination of in-house agreed and/or literature-based critical values. Communication by phone is still the preferred method of notification, but digital communication could help improve communication of critical results.
-
Sep 2, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |van ’t Veer
Transthoracic open procedure (TTO) was historically the preferred approach for treatment of giant hiatal hernias. However, the last decades transabdominal laparoscopic procedures (TAL) became the standard approach in many centres. The aim of the study was to compare short-term and midterm outcomes, as well as patient-reported outcome measures (PROMs, between TTO and TAL for giant hiatal hernias.
-
Aug 20, 2024 | 
academic.oup.com | KU Leuven |Vrije Universiteit Brussel |Hospitals Gasthuisberg Leuven
Detection of intact monoclonal immunoglobulin (Ig) D-λ by serum immunofixation electrophoresis (sIFE) is hampered by poor accessibility of anti-λ light chain (LC) antisera to the intact Ig (denoted as “unreactive/hidden” LC) (1). To illustrate this phenomenon, we present the case of a λ LC myeloma patient who consulted our tertiary center to obtain a second opinion. sIFE analysis was extended in our laboratory by using anti-δ, anti-ε, and anti-free LC (FLC) antisera (Fig. 1A).
-
Jul 5, 2024 | 
academic.oup.com | KU Leuven |Hospitals Gasthuisberg Leuven
The diagnostic workup for plasma cell dyscrasias comprises a comprehensive blood evaluation of electrolytes, renal function, hematological parameters, and monoclonal immunoglobulins (Ig). As illustrated in the accompanying case description, high concentrations of the latter may give rise to relevant preanalytical, analytical, and postanalytical challenges. Although infrequent, monoclonal proteins can behave as cryoglobulins, defined as Ig that reversibly precipitate in the cold.
-
May 23, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |KU Leuven |Van Craenenbroeck
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
-
Apr 17, 2024 | 
academic.oup.com | Hospitals Gasthuisberg Leuven |KU Leuven
Systemic antifungal therapy is critical for reducing the mortality from many invasive and chronic fungal infections. Triazole antifungals are the most frequently prescribed antifungals but require attention to dosing and drug interactions. Nearly 600 severe drug–drug interactions and over 1100 moderate interactions requiring dose modifications are described or anticipated with systemic antifungal agents (see https://www.aspergillus.org.uk/antifungal-drug-interactions/).
