Hugh Garavan

2 months ago | nature.com | Qingyang Li |Miao Cao |Dan Stein |Barbara Sahakian |Tianye Jia |Christelle Langley | +22 more

AbstractLaboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.

Jan 15, 2025 | biorxiv.org | Jeanette Alane Mumford |Michael I. Demidenko |James M. Bjork |Hugh Garavan

AbstractIn task functional magnetic resonance imaging (fMRI), collinearity between task regressors in a design matrix may impact power. Researchers often optimize task designs by assessing collinearity between task regressors to minimize downstream effects. However, some methods intended to reduce collinearity during optimization and data analysis may fail, in some cases introducing unintended bias into the parameter estimates.

Jan 9, 2025 | nature.com | Xinyang Yu |Zuo Zhang |Moritz Herle |Tobias Banaschewski |Gareth Barker |Herta Flor | +16 more

AbstractUnhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14–23 years) of ED-related psychopathology and brain maturation.

Jul 14, 2024 | nature.com | Runye Shi |Shitong Xiang |Tianye Jia |Trevor Robbins |Jujiao Kang |Tobias Banaschewski | +21 more

AbstractAdolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood.