Jujiao Kang

Nov 18, 2024 | nature.com | Yu Guo |Linbo Wang |Jujiao Kang |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractPathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred. Cox-proportional hazard models were applied to identify AD-associated proteins in different time intervals. Through linking to protein categories, changing sequences of protein z-scores can reflect pathophysiological evolutions.

Jul 15, 2024 | nature.com | Yue-Ting Deng |Jujiao Kang |Ying Zhu |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractThe genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes in 35 IMDs, among which 124 were novel genes. Several genes, including FLG which is associated with atopic dermatitis and asthma, showed converging evidence from both rare and common variants.

Jul 14, 2024 | nature.com | Runye Shi |Shitong Xiang |Tianye Jia |Trevor Robbins |Jujiao Kang |Tobias Banaschewski | +21 more

AbstractAdolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood.