Hussein Awada

May 30, 2024 | nature.com | Danai Dima |James Davis |Hussein Awada |Faiz Anwer |Shahzad Raza |Zahra Mahmoudjafari | +2 more

AbstractThe presence of extramedullary disease (EMD) has been associated with poor outcomes in patients with relapsed-refractory multiple myeloma (RRMM). Herein, we report the outcomes of RRMM patients who were treated with standard-of-care (SOC) chimeric antigen receptor (CAR) T-cell therapy and had active extraosseous EMD before the infusion. Data were retrospectively collected from patients at three US institutions with the intent to receive SOC CAR T.

May 11, 2024 | nature.com | Hussein Awada |Tariq Kewan |Danai Dima |Hassan Awada |Simona Pagliuca |Valeria Visconte

To the Editor:Karyotypic aberrations of chromosome (chr) 6 include duplications (trisomy 6 [+6]), deletions of its short arm (del6p), uniparental disomy 6p (UPD6p), as well as various microduplications and microdeletions. Lesions involving 6p are of particular interest as they point toward HLA locus involvement, including loss of heterozygosity and/or haploinsufficiency, as pathogenic drivers resulting from deletions and UPD6p [1, 2].

Apr 29, 2024 | nature.com | Hussein Awada |Valeria Visconte |Hassan Awada |James Cook

AbstractTherapy-related myeloid neoplasms (tMN) are complications of cytotoxic therapies. Risk of tMN is high in recipients of autologous hematopoietic stem cell transplantation (aHSCT). Acquisition of genomic mutations represents a key pathogenic driver but the origins, timing and dynamics, particularly in the context of preexisting or emergent clonal hematopoiesis (CH), have not been sufficiently clarified.

Jun 23, 2023 | nature.com | Hussein Awada |Faiz Anwer

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Feb 24, 2023 | mdpi.com | Hussein Awada |Valeria Visconte

Open AccessEditorialbyHussein Awada and Valeria Visconte * Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44106, USA*Author to whom correspondence should be addressed.