Tariq Kewan

Jul 17, 2024 | nature.com | Tariq Kewan |Olisaemeka Ogbue |Sudipto Mukherjee |Anjali Advani |James Cook |Hetty Carraway | +2 more

TO THE EDITOR:Extramedullary deposits of acute myeloid leukemia (eAML), constitute an unusual presentation or complication of AML, which can occur in isolation (isolated eAML) or in the context of a fully-blown leukemic process (synchronous eAML) either at diagnosis or relapse [1,2,3].

Jul 9, 2024 | nature.com | Olisaemeka Ogbue |Tariq Kewan |Valeria Visconte

To the Editor:Large granular lymphocytic leukemia (LGLL) can be defined as a chronic clonal proliferation of either cytotoxic T- (CTLs) or natural killer (NK) cells (T- or NK-LGLL) [1]. In a typical clinical situation, the disease affects elderly patients, who may present with neutropenia (39–62%) and/or anemia (up to 50%) [1], but also with a variety of autoimmune diseases [2].

May 11, 2024 | nature.com | Hussein Awada |Tariq Kewan |Danai Dima |Hassan Awada |Simona Pagliuca |Valeria Visconte

To the Editor:Karyotypic aberrations of chromosome (chr) 6 include duplications (trisomy 6 [+6]), deletions of its short arm (del6p), uniparental disomy 6p (UPD6p), as well as various microduplications and microdeletions. Lesions involving 6p are of particular interest as they point toward HLA locus involvement, including loss of heterozygosity and/or haploinsufficiency, as pathogenic drivers resulting from deletions and UPD6p [1, 2].