Ingrid Melle

Mar 18, 2024 | nature.com | Markos Tesfaye |Anne-Kristin Stavrum |Ingrid Melle |Ole A. Andreassen |Leticia M. Spindola

AbstractSex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of sex-stratified meta-analyses of epigenome-wide association studies (EWAS) of schizophrenia have not been investigated.

Dec 17, 2023 | nature.com | Lars T. Westlye |Thomas Bjella |Linn Sofie Sæther |Ingrid Melle |Ole A. Andreassen |Dag Alnæs | +2 more

AbstractThere is substantial cognitive heterogeneity among patients with schizophrenia (SZ) and bipolar disorders (BD). More knowledge about the magnitude and clinical correlates of performance variability could improve our understanding of cognitive impairments. Using double generalized linear models (DGLMs) we investigated cognitive mean and variability differences between patients with SZ (n = 905) and BD spectrum disorders (n = 522), and healthy controls (HC, n = 1170) on twenty-two variables.

Nov 26, 2023 | frontiersin.org | Feinstein Institutes |Ingrid Melle

Research on cerebellar mechanisms in psychotic disorders has gained momentum in the past few years. A growing body of evidence has emerged to show the critical role of the cerebellum in cognition (1, 2) and pathogenesis of psychosis (3–6), and to demonstrate its potential value in treatment of schizophrenia (7, 8).

Sep 13, 2023 | frontiersin.org | Ingrid Melle

The publication of case reports is essential within scientific literature in order to highlight data that provide essential information for disease management, to bring to attention atypical disease presentations, rare adverse effects of treatments, and to generate new hypotheses. Based on epistemological insights, it emerges that the idea that an observation can be reflected in a scientific discovery led to the issue of induction vs. deduction (1).

Aug 22, 2023 | frontiersin.org | Ingrid Melle

The present Research Topic aimed to deal with the latest research focused on the reliability or validity of clinical guidelines in the evaluation of schizophrenia. In addition, cultural, socioeconomic, or other factors relating to the application of clinical guidelines in schizophrenia were objectives of this Research Topic.