Jaakko Kaprio

Feb 26, 2024 | nature.com | Martin Broberg |Teemu Palviainen |Samuel Jones |Katja Valli |Samuli Ripatti |Elisabeth Widén | +2 more

AbstractNightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood.

Jan 24, 2024 | nature.com | Eija K. Laakkonen |Urho M Kujala |Kirsi Pietiläinen |Terho Lehtimäki |Jaakko Kaprio |Miina Ollikainen | +1 more

AbstractMetabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N = 268, aged 23–69 years). The findings were replicated in two cohorts from the same base population. One consisted of unrelated individuals (N = 1 564), and the other of twins (N = 293).

Nov 6, 2023 | nature.com | Fang Fang |Bryan C Quach |Jesse Marks |Veronika V. Odintsova |Yujing Xia |Laura J. Bierut | +7 more

AbstractCannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9436 participants (7795 European and 1641 African ancestry) from seven cohorts.