Terho Lehtimäki

Nov 11, 2024 | mdpi.com | Cillian Hourican |Jie Li |Pashupati P. Mishra |Terho Lehtimäki

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May 29, 2024 | bmjopen.bmj.com | Josephine Jackisch |Nazihah Muhamad Noor |Olli T. Raitakari |Terho Lehtimäki

Health behaviours will be measured by means of self-reported questionnaires in individuals aged 12, 15 and 18 years or when necessary, with support from parents. To identify clusters, we will consider smoking as current/past/never, alcohol use as hazardous/moderate/abstainer, physical activity as inactive/moderately active/sufficiently active and consumption of fruit and vegetables as sufficient/insufficient.

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Mar 3, 2024 | nature.com | Coral del Val |Alberto Mesa |Ramiro Salas |Gabriel de Erausquin |Terho Lehtimäki |Guillermo F. Poblete

AbstractGenome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of expression and function in genes related to human personality. We devised an innovative multi-omic approach to network analysis to identify the key control elements and interactions in multi-modular networks.

Jan 24, 2024 | nature.com | Eija K. Laakkonen |Urho M Kujala |Kirsi Pietiläinen |Terho Lehtimäki |Jaakko Kaprio |Miina Ollikainen | +1 more

AbstractMetabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N = 268, aged 23–69 years). The findings were replicated in two cohorts from the same base population. One consisted of unrelated individuals (N = 1 564), and the other of twins (N = 293).