Javier Lopez-Rios

Oct 9, 2024 | nature.com | Samuel Abassah-Oppong |Raquel Rouco |Cailyn H. Spurrell |Fabrice Darbellay |Jennifer A. Akiyama |Javier Lopez-Rios | +5 more

AbstractApproximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However, defining the regulatory functions embedded within these deserts is challenging due to their large size.

Mar 20, 2024 | nature.com | Zhuoxin Chen |Valentina Snetkova |Benjamin Clock |Iros Barozzi |Brandon J. Mannion |Ana Alcaina-Caro | +3 more

AbstractRemote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D) conformation of enhancers during mammalian development by generating high-resolution tissue-resolved contact maps for nearly a thousand enhancers with characterized in vivo activities in ten murine embryonic tissues.