-
Nov 21, 2024 | 
nature.com | Tao Shen |Siqi Sun |Di Liu |Jiuming Wang |Jin Xiao |Sheng Wang | +2 more
AbstractAccurate prediction of RNA three-dimensional (3D) structures remains an unsolved challenge. Determining RNA 3D structures is crucial for understanding their functions and informing RNA-targeting drug development and synthetic biology design. The structural flexibility of RNA, which leads to the scarcity of experimentally determined data, complicates computational prediction efforts.
-
Oct 11, 2024 | 
nature.com | Shiwei Wang |Ryan McMillan |Peng Yin |Laura Kiessling |Kylie S. Leung
AbstractExpansion microscopy (ExM) is in increasingly widespread use throughout biology because its isotropic physical magnification enables nanoimaging on conventional microscopes. To date, ExM methods either expand specimens to a limited range (~4–10× linearly) or achieve larger expansion factors through iterating the expansion process a second time (~15–20× linearly).
-
Oct 10, 2024 | 
nature.com | Peng Yin |Maigeng Zhou
AbstractElaborating and understanding disparities in the burden of cardiovascular disease attributable to high fasting plasma glucose is important to improve diabetes prevention and promote cardiovascular health. In this study, we pool data on 791,373 people aged 25 years and older from three population-based surveys, and estimate the burden of cardiovascular disease attributable to high fasting plasma glucose between 2010 and 2018 in China by age, sex, region and socio-demographic index.
-
Sep 17, 2024 | 
nature.com | Jiangdong Liu |Jinlei Qi |Peng Yin |Wei Liu |Ya Gao |Lu Zhou | +3 more
AbstractGlobal warming shifts daytime-only heatwaves to nighttime-only and day–night compound heatwaves. However, evidence on the cause-specific burdens of these heatwaves in a changing climate and ageing population is limited.
-
Aug 2, 2024 | 
studyfinds.org | Ya Gao |Peng Yin
(Photo by Jamie Street on Unsplash)SHANGHAI, China — The ups and downs of the stock market may be doing more than just affecting your wallet – they could be impacting your health in serious ways. A new study out of Fudan University in China shows a troubling link between stock market volatility and increased risks of heart attacks, strokes, and even suicide. The research, published in the journal Engineering, analyzed over 12 million deaths in China between 2013 and 2019.
-
Jul 31, 2024 | 
mdpi.com | Peng Yin |Yang Guo |Man Zhang |Jiaqiang Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
-
Jul 29, 2024 | 
nature.com | Kuanwei Sheng |Xueyang Yu |Gokul Gowri |Yunhao Zhai |Hanquan Su |Jingyi Luan | +8 more
Mass cytometry uses metal-isotope-tagged antibodies to label targets of interest, which enables simultaneous measurements of ~50 proteins or protein modifications in millions of single cells, but its sensitivity is limited. Here, we present a signal amplification technology, termed Amplification by Cyclic Extension (ACE), implementing thermal-cycling-based DNA in situ concatenation in combination with 3-cyanovinylcarbazole phosphoramidite-based DNA crosslinking to enable signal amplification simultaneously on >30 protein epitopes. We demonstrate the utility of ACE in low-abundance protein quantification with suspension mass cytometry to characterize molecular reprogramming during the epithelial-to-mesenchymal transition as well as the mesenchymal-to-epithelial transition. We show the capability of ACE to quantify the dynamics of signaling network responses in human T lymphocytes. We further present the application of ACE in imaging mass cytometry-based multiparametric tissue imaging to identify tissue compartments and profile spatial aspects related to pathological states in polycystic kidney tissues. Mass cytometry with signal amplification enables measurement of low-abundance proteins.
-
Jun 28, 2024 | 
jamanetwork.com | Ya Gao |Lin Lin |Peng Yin |Haidong Kan
Key PointsQuestion Do nighttime and daytime heat exposure differ in their association with dementia-related deaths? Findings In this case-crossover study of 132 573 dementia-related deaths, immediate and significant risk was associated with both nighttime and daytime heat. Stricter thresholds for nighttime heat were associated with a higher burden of dementia-related deaths compared with daytime heat.
-
Apr 26, 2024 | 
nature.com | Peng Yin
AbstractEstablish a new classification system of distal radius fracture based on computed tomographic (CT), and evaluate its reliability and reproducibility preliminarily, and provide a new theoretical reference for clinicians to use the clinical classification system. The imaging data and clinical data of 204 inpatients with distal radius fracture during 6 years from January 1, 2014 to January 1, 2019 in orthopaedic department were analyzed retrospectively and classified based on CT.
-
Sep 17, 2023 | 
biorxiv.org | Xuewei Liu |Peng Yin |Xu Li |Ruiting Shen
AbstractAvian infectious bronchitis (IB) is an acute highly contagious respiratory infectious disease caused by avian infectious bronchitis virus (IBV), causing serious economic losses to poultry industry. Forsythiaside A (FTA) is a phenylethanol glycoside compound in the fruit of Forsythia suspensa, which is widely used for inflammatory respiratory tract disease, including viral infected inflammation. In this study, the mechanism of FTA against IBV was researched.
