Jiguang Wang

Oct 30, 2024 | nature.com | Duo Xie |Shanjun Deng |Kun Wang |Hao Zhang |Xuefei Li |Da Zhou | +5 more

AbstractUnravelling the origin and evolution of precancerous lesions is crucial for effectively preventing malignant transformation, yet our current knowledge remains limited1,2,3. Here we used a base editor-enabled DNA barcoding system4 to comprehensively map single-cell phylogenies in mouse models of intestinal tumorigenesis induced by inflammation or loss of the Apc gene.

Sep 2, 2024 | dx.doi.org | Lunxiang Zhang |Rui Jin |Jiguang Wang |Haiyuan Yao

Mar 4, 2024 | nature.com | Xing Cheng |Jing An |Jitong Lou |Qisheng Gu |Yilin Wang |Jay Anand | +10 more

AbstractAlmost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown.

Jan 24, 2024 | mdpi.com | Jiguang Wang |Feng Xu |Xudong Chen |Jiaqiang Li

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Dec 4, 2023 | nature.com | Rebecca J. Leeman-Neill |Dong Song |Ludivine Wacheul |Sameer Singh |Aditya Y. Sarode |Kishore Gollapalli | +6 more

AbstractWhole-genome sequencing of longitudinal tumor pairs representing transformation of follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements (double-hit lymphoma) identified coding and noncoding genomic alterations acquired during lymphoma progression.