Kerry J. Ressler

Jun 14, 2024 | nature.com | Kerry J. Ressler

The world of neuroscience and social behavior lost a titan with the passing of Larry Young, PhD, on March 21, 2024, a luminary whose contributions illuminated the intricacies of mammalian social connection. Dr. Young was accepted into ACNP membership in 2009. With a heavy heart, we bid farewell to a visionary whose legacy will endure for generations to come.

Mar 31, 2024 | nature.com | Adam X. Maihofer |Vasiliki Michopoulos |Renato Polimanti |Soraya Seedat |Elizabeth Mikita |Alicia Smith | +5 more

AbstractObservational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD and co-morbid autoimmune conditions. We investigated the shared genetic contributions and causal relationships between PTSD, 18 autoimmune diseases, and 3 immune/inflammatory biomarkers.

May 9, 2023 | nature.com | Poornima Kumar |Nikolaos P. Daskalakis |Kerry J. Ressler

AbstractThe pituitary adenylate cyclase-activating polypeptide (PACAP) system is implicated in posttraumatic stress disorder (PTSD) and related amygdala-mediated arousal and threat reactivity. PTSD is characterized by increased amygdala reactivity to threat and, more recently, aberrant intrinsic connectivity of the amygdala with large-scale resting state networks, specifically the default mode network (DMN).

Mar 13, 2023 | nature.com | Dongjing Liu |Brian K. Fennessy |Esther Cheng |Joseph D. Buxbaum |Enrico Domenici |Dheeraj Malhotra | +21 more

AbstractSchizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1.