Renato Polimanti

Jul 1, 2024 | ajp.psychiatryonline.org | Renato Polimanti

Depression is a psychiatric disorder affecting a large proportion of individuals, with major social and economic consequences for families and society. In the past 10 years, large-scale studies have revolutionized our understanding of depression predisposition. In particular, genome-wide association studies (GWASs) of millions of participants have uncovered hundreds of loci contributing to the polygenic architecture of depressive disorders and symptoms (1, 2).

Mar 31, 2024 | nature.com | Adam X. Maihofer |Vasiliki Michopoulos |Renato Polimanti |Soraya Seedat |Elizabeth Mikita |Alicia Smith | +5 more

AbstractObservational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD and co-morbid autoimmune conditions. We investigated the shared genetic contributions and causal relationships between PTSD, 18 autoimmune diseases, and 3 immune/inflammatory biomarkers.

Jan 4, 2024 | nature.com | Brenda Cabrera-Mendoza |Chadi G Abdallah |John H Krystal |Joel Gelernter |Janitza L. Montalvo-Ortiz |Renato Polimanti

Correction to: Neuropsychopharmacology https://doi.org/10.1038/s41386-023-01747-5, published online 17 October 2023In the original article, the author name Sheila Nagamatsu was incorrectly given as ‘Sheila Nagamastu’. The original article has been corrected. About this articleTamman, A.J.F., Koller, D., Nagamatsu, S. et al. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacol. (2024).

Jan 4, 2024 | nature.com | Xiangrui Meng |Daniel F Levey |Dora Koller |Mark Adams |Miguel E. Rentería |Dan Stein | +42 more

AbstractMost genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).

Nov 20, 2023 | nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more

AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.