Kevin Deane

Sep 6, 2024 | ard.bmj.com | Kevin Deane |V Michael Holers |Paul Emery |Kulveer Mankia

IntroductionThe term ‘risk’ suggests that an action or event might happen. Importantly, it implies the event is associated with harm. In medicine, risk is related to factors (ie, risk or protective factors) that influence the likelihood of disease onset, or worsening of an existing disease, in individuals who have inherited or acquired those risk factors.

Nov 8, 2023 | nature.com | fan zhang |Anna Jonsson |Michelle Curtis |Maria Gutierrez-Arcelus |Javier Rangel-Moreno |Kathryne E. Marks | +18 more

AbstractRheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction1. There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined pathogenic diversity1,2. Here, to deconstruct the cell states and pathways that characterize this pathogenic heterogeneity, we profiled the full spectrum of cells in inflamed synovium from patients with rheumatoid arthritis.