Kuniaki Sato

Jan 8, 2025 | nature.com | Farhoud Faraji |Sydney I. Ramirez |Kuniaki Sato |Kenneth Kim |Quinton Smith |Ophir Klein

AbstractTumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.