Lachelle D. Weeks

Dec 10, 2024 | onlinelibrary.wiley.com | Shyam Patel |Lachelle D. Weeks

Approximately a decade ago, clonal haematopoiesis (CH), caused by acquired mutations in genes associated with myeloid neoplasia (MN), was initially characterized as a common age-related condition associated with an increased risk for blood cancers such as myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).1 In CH, genetically related haematopoietic stem and progenitor cells (HSPCs) have a fitness advantage compared to normal HSPCs due to somatic mutations and make an outsized...

Oct 28, 2024 | digitalcommons.library.tmc.edu | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks |Abhishek Niroula

IMPORTANCE: Clonal hematopoiesis (CH) with acquired pathogenic variants in myeloid leukemia driver genes is common in older adults but of unknown prognostic value. OBJECTIVE: To investigate the prevalence of CH and the utility of the CH risk score (CHRS) in estimating all-cause and disease-specific mortality in older adults with CH.

Jan 17, 2024 | jamanetwork.com | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks

Key PointsQuestion  Is the clonal hematopoiesis (CH) risk score associated with all-cause and disease-specific mortality in older adults with CH? Findings  In this cohort study that included 3871 individuals without hematologic malignant neoplasms at baseline, 24.2% had CH.

Nov 2, 2023 | acrjournals.onlinelibrary.wiley.com | Michelle L. Robinette |Lachelle D. Weeks |Ryan Kramer |MRIDUL AGRAWAL

INTRODUCTION Giant cell arteritis (GCA) is a systemic granulomatous vasculitis that affects people over the age of 50.1 Because of the risk of permanent vision loss caused by ischemic damage to the ophthalmic vasculature, GCA is a medical emergency that requires rapid recognition and treatment with high-dose steroids.