-
Nov 29, 2024 | 
biorxiv.org | Liam Johnson |James Casaletto |Caitlin R Proctor |Lauren Sanders
AbstractThe genetic perturbations caused by spaceflight on biological systems tend to have a system-wide effect which is often difficult to deconvolute into individual signals with specific points of origin. Single cell multi-omic data can provide a profile of the perturbational effects but does not necessarily indicate the initial point of interference within a network.
-
Oct 15, 2024 | 
nature.com | JangKeun Kim |Francisco J. Enguita |Sylvain V Costes |Ryan Scott |Lauren Sanders |David Furman | +3 more
Correction to: Communications Biology https://doi.org/10.1038/s42003-024-06944-6, published online 05 October 2024In the Acknowledgement section, the L.I.G. was supported by the US Army Medical Research Command (award W81XWH2110402) was omitted. The original article has been corrected.
-
Oct 4, 2024 | 
nature.com | JangKeun Kim |Francisco J. Enguita |Sylvain V Costes |Ryan Scott |Lauren Sanders |David Furman | +3 more
AbstractIn the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses.
-
Sep 27, 2024 | 
medrxiv.org | Yvonne Vasquez |Holly C. Beale |Lauren Sanders |Alfred Geoffrey Lyle
The authors have declared no competing interest. This study/authors were funded by the following: California Initiative to Advance Precision Medicine (CIAPM), AACR NextGen Award for Transformative Cancer Research, The St. Baldrick's Foundation, The Live for Others Foundation, Stanford Medicine Children's Health and Stanford University School of Medicine, and Howard Hughes Medical Institute.
-
Jun 10, 2024 | 
nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more
AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
-
Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more
AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
-
Jun 10, 2024 | 
nature.com | Begum Mathyk |Alexander Quaas |Fathi Karouia |Nicolas Nelson |Ozlem Guzeloglu-Kayisli |Lauren Sanders | +12 more
AbstractAs the space industry grows exponentially and aspirations for space travel expand, we are entering a new era where we will very likely become an interplanetary species. Although reproduction is an essential human function and necessary for species survival, we have remarkably little knowledge regarding the impact of space travel on the female reproductive system.
-
May 13, 2024 | 
nature.com | Lauren Sanders |Ryan Scott |San-huei Lai Polo |Rachel Gilbert |Eliah G. Overbey |JangKeun Kim | +1 more
AbstractThe increasing accessibility of commercial and private space travel necessitates a profound understanding of its impact on human health. The NASA Open Science Data Repository (OSDR) provides transparent and FAIR access to biological studies, notably the SpaceX Inspiration4 (I4) mission, which amassed extensive data from civilian astronauts. This dataset encompasses omics and clinical assays, facilitating comprehensive research on space-induced biological responses.
-
Apr 25, 2024 | 
nature.com | Lauren Sanders |Sylvain V Costes
AbstractOne of the greatest challenges of humanity for deep space exploration is to fully understand how altered gravitational conditions affect human physiology. It is evident that the spaceflight environment causes multiple alterations to musculoskeletal, cardiovascular, immune and central nervous systems, to name a few known effects.
-
Jan 27, 2024 | 
biorxiv.org | Anurag Sakharkar |Kiven Erique Lukong |Lauren Sanders |Sylvain V Costes
AbstractSpace exploration has captured the imagination of humanity for generations. From the first steps on the moon to the recent Mars rover and Artemis lunar exploration missions, space travel has always been an ambitious goal for humanity. However, as we venture further into space and prepare for long-term missions to other planets, the physiological and health risks associated with prolonged space travel are becoming more prominent.
