Nature Methods

Nature Methods is a scientific journal that is published monthly and focuses on innovative scientific techniques. Launched in 2004, it is produced by the Nature Publishing Group. Similar to other journals in the Nature family, it does not have an external editorial board; instead, an internal team handles editorial decisions. However, the review process includes peer evaluations by outside experts. As per the Journal Citation Reports, this journal achieved an impressive impact factor of 32.072 in 2014, placing it at the top of the "Biochemical Research Methods" category.

International, Trade/B2B

English

Journal

Outlet metrics

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Ranking

Global

#1791

United States

#1173

Science and Education/Biology

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Articles

Harvard vs Trump: what this epic battle means for science

2 days ago | nature.com | Jeff Tollefson

Mary Rice was among hundreds of scientists at Harvard University who watched helplessly as millions of dollars in research funds disappeared in an instant in mid-May. Two of the pulmonologist’s grants were formally cancelled as part of a series of punitive actions taken by the administration of US President Donald Trump against the university. Little justification was given to Rice aside from a statement that her research does not align with government priorities.
Enhancing CAR-T cell efficacy through IFN ablation

2 days ago | nature.com | M. Teresa Villanueva

Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of haematological malignancies. However, challenges — such as relapse owing to insufficient persistence of CAR-T cells — remain. Now, writing in Science Translational Medicine, Bailey et al. have demonstrated that knocking out the interferon-gamma (IFN-γ) receptor (IFN-γR) in CAR-T cells enhances their efficacy and persistence in models of haematological and solid tumours.
Is AI watching you? The hidden links between research and surveillance

3 days ago | nature.com | Benjamin Thompson |Shamini Bundell

Download the Nature Podcast 25 June 2025We’d like to learn more about our listeners, please help us out by filling in this short survey. In this episode:00:45 Is AI-research being co-opted to keep track of people? A significant amount of research in the AI field of computer vision is being used to analyse humans in ways that support the development of surveillance technologies, according to new research.
Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling - Cell Discovery

3 days ago | nature.com | Chongzhao You |Shimeng Guo |Tianwei Zhang |Xinheng He |Youwei Xu |Yi Jiang | +1 more

AbstractMaintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activation remain incompletely understood. Here we present high-resolution cryo-electron microscopy structures of GPR4 in complex with G proteins under physiological and acidic pH conditions.
Comparison of induction with arsenic trioxide or chemotherapy in a real-world cohort of patients with high-risk acute promyelocytic leukemia - Leukemia

4 days ago | nature.com | Delphine Lebon |Nicolas Duployez |Christophe Willekens |Thomas Cluzeau |Christian Récher |Mathilde Hunault-Berger | +1 more

AbstractFront-line treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) is superior to standard ATRA and chemotherapy (CHT) in patients with low-/intermediate-risk acute promyelocytic leukemia (APL). However, for high-risk (HR) patients (defined as those with a white blood cell count ≥ 10×10⁹/L), the role of ATRA-ATO is subject to debate, and study data are scarce.
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity - Signal Transduction and Targeted Therapy

1 week ago | nature.com | Zhenzhen Wang |Joshua Gardner |Xiaoli Meng

AbstractSevere cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease susceptibility. Using dapsone hypersensitivity syndrome (DHS) as a paradigm for SCARs, we show that the DHS patients harbor a sex-related global reduction in blood NK cells, contributing to the higher incidence of reactions in females.
A survey of pathogenic involvement in non-communicable human diseases - Communications Medicine

1 week ago | nature.com | Michael Lape |Daniel J. Schnell |Shannon O’Connor |Nathan Salomonis |Lisa Martin |Leah C. Kottyan

AbstractMany relationships between pathogens and human disease are well-established. However, only a small fraction involve diseases considered non-communicable (NCDs). In this study, we sought to leverage the vast amount of newly available electronic health record data to identify potentially novel pathogen-NCD associations and find additional evidence supporting known associations.
Early grant success attracts more funding: study of 100,000 applicants hints at why

1 week ago | nature.com | Holly Else

Perseverance is key when it comes to securing science funding, found an analysis of more than 100,000 grant applicants that looked at how early success affects future prospects. The research shows how the Matthew effect — a phenomenon describing how those with an early advantage or success tend to accumulate more over time — could be driving inequity in academia. Previous work has suggested that those who win funding early in their career are more successful later down the line.
Developing astronomers in Africa: ‘We wanted to create a discipline’

1 week ago | nature.com | Sarah Wild

In 2005, when South Africa and its partner countries in Africa submitted a proposal to host the world’s largest radio telescope, called the Square Kilometre Array, the continent had five radioastronomers, all based in South Africa. That year, the country embarked on a targeted human-capital development programme to develop talent needed to build, operate and use radio telescopes, which collect radio signals emitted by celestial objects.
Bringing men into conversations about parenting in academia

1 week ago | nature.com | Amanda Heidt

Carers working in academia — the vast majority of whom are women — face disproportionate career burdens, and the cultural shift needed to correct that imbalance will require considerable action from men. To advance that cause, the international non-profit organization Mothers in Science (MIS) is launching a global awareness campaign to amplify the voices of fathers who are redefining fatherhood and advancing gender equity.