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Feb 2, 2025 | 
biorxiv.org | Zhiyu Kang |Li Chen |Peng Wei |Zhichao Xu
AbstractMediation analysis helps uncover how exposures impact outcomes through intermediate variables. Traditional mean-based total mediation effect measures can suffer from the cancellation of opposite component-wise effects and existing methods often lack the power to capture weak effects in high-dimensional mediators. Additionally, most existing work has focused on continuous outcomes, with limited attention to binary outcomes, particularly in case-control studies.
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Jan 14, 2025 | 
journals.aps.org | Li Chen
Constructing and manipulating quantum states in fast-rotating Bose-Einstein condensates (BECs) has long stood as a significant challenge as the rotating speed approached a critical velocity. Although a recent experiment [R. J. Fletcher et al., Science 372, 1318 (2021)] has realized the geometrically squeezed state of the guiding-center mode, the remaining degree of freedom, the cyclotron mode, remains unsqueezed due to the large energy gap of the Landau levels.
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Jan 13, 2025 | 
mdpi.com | Li Chen
1. IntroductionNowadays, retailers of digital goods such as e-books, online newspapers, and mobile applications (hereinafter “retailers”) often use strategies in multiple aspects. In the aspect of revenue strategies, they need to decide whether to adopt an ad-supported model, subscription-based model, or other models [1]. For instance, while YouTube chooses an ad-supported model, Netflix adopts a subscription-based model.
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Dec 23, 2024 | 
mdpi.com | Li Chen
1. IntroductionThe analysis of rock thin section imagery represents an indispensable geological exploration [1] tool for understanding and recognizing the composition of the Earth. Furthermore, it serves as a significant evaluation method in oil and gas exploration and development [2]. This technique can be employed to identify petrological properties of reservoir rocks [3], ascertain genetic types [4], and differentiate the characteristics of reservoir space and pore structure [5].
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Dec 11, 2024 | 
mdpi.com | Siyu Zhang |Weiyan Hu |Li Chen |Yu ZHANG
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Oct 28, 2024 | 
nature.com | Md. Azahar Ali |Kawsar Ahmed |Li Chen |Mohammad Ali Moni |Tasmin Karim |Md. Shazzad Hossain Shaon | +1 more
RNA 5-methyluridine (m5U) sites play a significant role in understanding RNA modifications, which influence numerous biological processes such as gene expression and cellular functioning. Consequently, the identification of m5U sites can play a vital role in the integrity, structure, and function of RNA molecules. Therefore, this study introduces GRUpred-m5U, a novel deep learning-based framework based on a gated recurrent unit in mature RNA and full transcript RNA datasets. We used three descriptor groups: nucleic acid composition, pseudo nucleic acid composition, and physicochemical properties, which include five feature extraction methods ENAC, Kmer, DPCP, DPCP type 2, and PseDNC. Initially, we aggregated all the feature extraction methods and created a new merged set. Three hybrid models were developed employing deep-learning methods and evaluated through 10-fold cross-validation with seven evaluation metrics. After a comprehensive evaluation, the GRUpred-m5U model outperformed the other applied models, obtaining 98.41% and 96.70% accuracy on the two datasets, respectively. To our knowledge, the proposed model outperformed all the existing state-of-the-art technology. The proposed supervised machine learning model was evaluated using unsupervised machine learning techniques such as principal component analysis (PCA), and it was observed that the proposed method provided a valid performance for identifying m5U. Considering its multi-layered construction, the GRUpred-m5U model has tremendous potential for future applications in the biological industry. The model, which consisted of neurons processing complicated input, excelled at pattern recognition and produced reliable results. Despite its greater size, the model obtained accurate results, essential in detecting m5U.
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Oct 27, 2024 | 
mdpi.com | Jie Zhu |Mengyao Zhu |Li Chen |Li Luo
1. IntroductionThe placement of urban gas stations, as critical support facilities for urban road transportation, profoundly impacts both the orderly development of cities and the daily lives of residents [1,2,3]. Traditionally, profit-driven motives and investment incentives have led to the indiscriminate approval and construction of gas stations, resulting in disorganized layouts and inefficient distribution [4].
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Oct 21, 2024 | 
chinadailyhk.com | Li Chen
The 2024 Policy Address delivered by Hong Kong Chief Executive John Lee Ka-chiu on Oct 16 has introduced a new set of policy measures to promote Hong Kong’s innovation and technology (I&T) development. The government will draw up a medium-to-long-term development plan for new industrialization in Hong Kong.
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Oct 20, 2024 | 
chinadailyasia.com | Li Chen
The 2024 Policy Address delivered by Hong Kong Chief Executive John Lee Ka-chiu on Oct 16 has introduced a new set of policy measures to promote Hong Kong’s innovation and technology (I&T) development. The government will draw up a medium-to-long-term development plan for new industrialization in Hong Kong.
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Oct 11, 2024 | 
nature.com | Li Chen
AbstractThis study aims to assess how the construction patterns within residential communities influence the adolescent myopia using general survey. In a private high school from a megacity in mid-west China, a questionnaire gathered data on the 10th-grade students’ level of myopia, home address, and some potential confounding factors.
