Zhiyu Kang

2 months ago | biorxiv.org | Zhiyu Kang |Li Chen |Peng Wei |Zhichao Xu

AbstractMediation analysis helps uncover how exposures impact outcomes through intermediate variables. Traditional mean-based total mediation effect measures can suffer from the cancellation of opposite component-wise effects and existing methods often lack the power to capture weak effects in high-dimensional mediators. Additionally, most existing work has focused on continuous outcomes, with limited attention to binary outcomes, particularly in case-control studies.

Oct 24, 2023 | mdpi.com | Kaifeng Yang |Zhiyu Kang |Weihua Guan |Sahar Lotfi-Emran

1. IntroductionDespite the success of vaccines, the ability to identify individuals at risk of severe COVID-19 disease is a persistent need. Certain individuals remain at high risk, and healthcare professionals can make better decisions with accurate information about whether or not their patients are at high risk of developing severe outcomes [1].