Manuel Mattheisen

Mar 27, 2024 | nature.com | Nora I. Strom |Christie L. Burton |René Pool |James J. Crowley |Jouke-Jan Hottenga |Henrik R. Larsson | +6 more

AbstractWhile 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life.

Apr 10, 2023 | biologicalpsychiatryjournal.com | Yuri Milaneschi |Manuel Mattheisen |Dongmei Yu |Nora I. Strom

Significant differences in subcortical volumes, cortical thickness and surface area have been shown in individuals with obsessive compulsive disorder (OCD) compared to controls. Both propensity to OCD and variability in brain morphometry are influenced by genetic factors. These genetic influences typically have a polygenic architecture and can be quantified using polygenic risk scoring (PRS) methods.